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Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.

Identifieur interne : 000668 ( Main/Exploration ); précédent : 000667; suivant : 000669

Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.

Auteurs : James Slack [Royaume-Uni] ; Michael H. Albert [Allemagne] ; Dmitry Balashov [Russie] ; Bernd H. Belohradsky [Allemagne] ; Alice Bertaina [Italie] ; Jack Bleesing [États-Unis] ; Claire Booth [Royaume-Uni] ; Jochen Buechner [Norvège] ; Rebecca H. Buckley [États-Unis] ; Marie Ouachée-Chardin [France] ; Elena Deripapa [Russie] ; Katarzyna Drabko [Pologne] ; Mary Eapen ; Tobias Feuchtinger [Allemagne] ; Andrea Finocchi ; H Bobby Gaspar [Royaume-Uni] ; Sujal Ghosh [Allemagne] ; Alfred Gillio [États-Unis] ; Luis I. Gonzalez-Granado [Espagne] ; Eyal Grunebaum [Canada] ; Tayfun Güngör [Suisse] ; Carsten Heilmann [Danemark] ; Merja Helminen [Finlande] ; Kohei Higuchi [Japon] ; Kohsuke Imai [Japon] ; Krzysztof Kalwak [Pologne] ; Nubuo Kanazawa [Japon] ; Gülsün Karasu [Turquie] ; Zeynep Y. Kucuk [États-Unis] ; Alexandra Laberko [Russie] ; Andrzej Lange [Pologne] ; Nizar Mahlaoui [France] ; Roland Meisel [Allemagne] ; D. Moshous [France] ; Hideki Muramatsu [Japon] ; Suhag Parikh [États-Unis] ; Srdjan Pasic [Serbie] ; Irene Schmid [Allemagne] ; Catharina Schuetz [Allemagne] ; Ansgar Schulz [Allemagne] ; Kirk R. Schultz [Canada] ; Peter J. Shaw [Australie] ; Mary A. Slatter [Royaume-Uni] ; Karl-Walter Sykora [Allemagne] ; Shinobu Tamura [Japon] ; Mervi Taskinen [Finlande] ; Angela Wawer [Allemagne] ; Beata Wolska-Kus Nierz [Pologne] ; Morton J. Cowan ; Alain Fischer [France] ; Andrew R. Gennery [Royaume-Uni]

Source :

RBID : pubmed:28392333

Abstract

Rare DNA breakage repair disorders predispose to infection and lymphoreticular malignancies. Hematopoietic cell transplantation (HCT) is curative, but coadministered chemotherapy or radiotherapy is damaging because of systemic radiosensitivity. We collected HCT outcome data for Nijmegen breakage syndrome, DNA ligase IV deficiency, Cernunnos-XRCC4-like factor (Cernunnos-XLF) deficiency, and ataxia-telangiectasia (AT).

DOI: 10.1016/j.jaci.2017.02.036
PubMed: 28392333


Affiliations:


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<name sortKey="Ouachee Chardin, Marie" sort="Ouachee Chardin, Marie" uniqKey="Ouachee Chardin M" first="Marie" last="Ouachée-Chardin">Marie Ouachée-Chardin</name>
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<nlm:affiliation>Paediatric BMT Unit, Robert Debre Hospital, Paris, France.</nlm:affiliation>
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<name sortKey="Finocchi, Andrea" sort="Finocchi, Andrea" uniqKey="Finocchi A" first="Andrea" last="Finocchi">Andrea Finocchi</name>
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<nlm:affiliation>Department of Systems Medicine, University of Rome "Tor Vergata", Unit of Immune and Infectious Diseases, Children's Hospital Bambino Gesù, Rome, Itlay.</nlm:affiliation>
<wicri:noCountry code="subField">Itlay</wicri:noCountry>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea>
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<country xml:lang="fr">Allemagne</country>
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<nlm:affiliation>Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ.</nlm:affiliation>
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<region type="state">New Jersey</region>
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<name sortKey="Gonzalez Granado, Luis I" sort="Gonzalez Granado, Luis I" uniqKey="Gonzalez Granado L" first="Luis I" last="Gonzalez-Granado">Luis I. Gonzalez-Granado</name>
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<nlm:affiliation>Immunodeficiencies, Hematology & Oncology Unit, Pediatrics, Hospital 12 Octubre, and Universidad Complutense, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
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<settlement type="city">Madrid</settlement>
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<name sortKey="Grunebaum, Eyal" sort="Grunebaum, Eyal" uniqKey="Grunebaum E" first="Eyal" last="Grunebaum">Eyal Grunebaum</name>
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<nlm:affiliation>Division of Immunology and Allergy, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Immunology and Allergy, Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
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<name sortKey="Gungor, Tayfun" sort="Gungor, Tayfun" uniqKey="Gungor T" first="Tayfun" last="Güngör">Tayfun Güngör</name>
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<nlm:affiliation>Division of Stem Cell Transplantation, University Children's Hospital Zürich, Zürich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Stem Cell Transplantation, University Children's Hospital Zürich, Zürich</wicri:regionArea>
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<settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
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</affiliation>
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<name sortKey="Heilmann, Carsten" sort="Heilmann, Carsten" uniqKey="Heilmann C" first="Carsten" last="Heilmann">Carsten Heilmann</name>
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<placeName>
<settlement type="city">Copenhague</settlement>
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<name sortKey="Helminen, Merja" sort="Helminen, Merja" uniqKey="Helminen M" first="Merja" last="Helminen">Merja Helminen</name>
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<nlm:affiliation>Paediatric Research Center, University Hospital of Tampere, Tampere, Finland.</nlm:affiliation>
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<name sortKey="Higuchi, Kohei" sort="Higuchi, Kohei" uniqKey="Higuchi K" first="Kohei" last="Higuchi">Kohei Higuchi</name>
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<name sortKey="Imai, Kohsuke" sort="Imai, Kohsuke" uniqKey="Imai K" first="Kohsuke" last="Imai">Kohsuke Imai</name>
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<nlm:affiliation>Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo</wicri:regionArea>
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<name sortKey="Kalwak, Krzysztof" sort="Kalwak, Krzysztof" uniqKey="Kalwak K" first="Krzysztof" last="Kalwak">Krzysztof Kalwak</name>
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<nlm:affiliation>Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Kanazawa, Nubuo" sort="Kanazawa, Nubuo" uniqKey="Kanazawa N" first="Nubuo" last="Kanazawa">Nubuo Kanazawa</name>
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<nlm:affiliation>Department of Dermatology, Wakayama Medical University, Wakayama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Dermatology, Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Karasu, Gulsun" sort="Karasu, Gulsun" uniqKey="Karasu G" first="Gülsün" last="Karasu">Gülsün Karasu</name>
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<nlm:affiliation>Bahcesehir University Faculty of Medicine, Göztepe Medicalpark Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Bahcesehir University Faculty of Medicine, Göztepe Medicalpark Hospital Pediatric Stem Cell Transplantation Unit, Istanbul</wicri:regionArea>
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</author>
<author>
<name sortKey="Kucuk, Zeynep Y" sort="Kucuk, Zeynep Y" uniqKey="Kucuk Z" first="Zeynep Y" last="Kucuk">Zeynep Y. Kucuk</name>
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<nlm:affiliation>Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati</wicri:cityArea>
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</author>
<author>
<name sortKey="Laberko, Alexandra" sort="Laberko, Alexandra" uniqKey="Laberko A" first="Alexandra" last="Laberko">Alexandra Laberko</name>
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<nlm:affiliation>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow</wicri:regionArea>
<placeName>
<settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
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<name sortKey="Lange, Andrzej" sort="Lange, Andrzej" uniqKey="Lange A" first="Andrzej" last="Lange">Andrzej Lange</name>
<affiliation wicri:level="1">
<nlm:affiliation>Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences / Lower Silesian Center for Cellular Transplantation, Wrocław, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences / Lower Silesian Center for Cellular Transplantation, Wrocław</wicri:regionArea>
<wicri:noRegion>Wrocław</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mahlaoui, Nizar" sort="Mahlaoui, Nizar" uniqKey="Mahlaoui N" first="Nizar" last="Mahlaoui">Nizar Mahlaoui</name>
<affiliation wicri:level="3">
<nlm:affiliation>French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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</author>
<author>
<name sortKey="Meisel, Roland" sort="Meisel, Roland" uniqKey="Meisel R" first="Roland" last="Meisel">Roland Meisel</name>
<affiliation wicri:level="3">
<nlm:affiliation>Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
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</affiliation>
</author>
<author>
<name sortKey="Moshous, D" sort="Moshous, D" uniqKey="Moshous D" first="D" last="Moshous">D. Moshous</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris</wicri:regionArea>
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<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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<author>
<name sortKey="Muramatsu, Hideki" sort="Muramatsu, Hideki" uniqKey="Muramatsu H" first="Hideki" last="Muramatsu">Hideki Muramatsu</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya</wicri:regionArea>
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</author>
<author>
<name sortKey="Parikh, Suhag" sort="Parikh, Suhag" uniqKey="Parikh S" first="Suhag" last="Parikh">Suhag Parikh</name>
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<nlm:affiliation>Duke University School of Medicine, Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
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<wicri:cityArea>Duke University School of Medicine, Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham</wicri:cityArea>
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<author>
<name sortKey="Pasic, Srdjan" sort="Pasic, Srdjan" uniqKey="Pasic S" first="Srdjan" last="Pasic">Srdjan Pasic</name>
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<nlm:affiliation>Mother and Child Health Institute, Medical Faculty, University of Belgrade, Belgrade, Serbia.</nlm:affiliation>
<country xml:lang="fr">Serbie</country>
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<author>
<name sortKey="Schmid, Irene" sort="Schmid, Irene" uniqKey="Schmid I" first="Irene" last="Schmid">Irene Schmid</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
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<author>
<name sortKey="Schuetz, Catharina" sort="Schuetz, Catharina" uniqKey="Schuetz C" first="Catharina" last="Schuetz">Catharina Schuetz</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm</wicri:regionArea>
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<author>
<name sortKey="Schulz, Ansgar" sort="Schulz, Ansgar" uniqKey="Schulz A" first="Ansgar" last="Schulz">Ansgar Schulz</name>
<affiliation wicri:level="3">
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
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<name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R" last="Schultz">Kirk R. Schultz</name>
<affiliation wicri:level="1">
<nlm:affiliation>Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
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<author>
<name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J" last="Shaw">Peter J. Shaw</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Oncology, Children's Hospital at Westmead, Westmead, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Oncology, Children's Hospital at Westmead, Westmead</wicri:regionArea>
<wicri:noRegion>Westmead</wicri:noRegion>
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</author>
<author>
<name sortKey="Slatter, Mary A" sort="Slatter, Mary A" uniqKey="Slatter M" first="Mary A" last="Slatter">Mary A. Slatter</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
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<author>
<name sortKey="Sykora, Karl Walter" sort="Sykora, Karl Walter" uniqKey="Sykora K" first="Karl-Walter" last="Sykora">Karl-Walter Sykora</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Pediatric Hematology Oncology, Hannover Medical, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Hematology Oncology, Hannover Medical, Hannover</wicri:regionArea>
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<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
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<author>
<name sortKey="Tamura, Shinobu" sort="Tamura, Shinobu" uniqKey="Tamura S" first="Shinobu" last="Tamura">Shinobu Tamura</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Hematology and Oncology, Wakayama Medical University, Wakayama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hematology and Oncology, Wakayama Medical University, Wakayama</wicri:regionArea>
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</author>
<author>
<name sortKey="Taskinen, Mervi" sort="Taskinen, Mervi" uniqKey="Taskinen M" first="Mervi" last="Taskinen">Mervi Taskinen</name>
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<nlm:affiliation>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Helsinki University Hospital, Helsinki</wicri:regionArea>
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</author>
<author>
<name sortKey="Wawer, Angela" sort="Wawer, Angela" uniqKey="Wawer A" first="Angela" last="Wawer">Angela Wawer</name>
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<nlm:affiliation>Paediatric Haematology & Oncology, Kinderklinik der Technische Universität München, Krankenhaus München-Schwabing, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Paediatric Haematology & Oncology, Kinderklinik der Technische Universität München, Krankenhaus München-Schwabing, Munich</wicri:regionArea>
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<region type="land" nuts="1">Bavière</region>
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<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
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<name sortKey="Wolska Kus Nierz, Beata" sort="Wolska Kus Nierz, Beata" uniqKey="Wolska Kus Nierz B" first="Beata" last="Wolska-Kus Nierz">Beata Wolska-Kus Nierz</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Immunology, Children's Memorial Health Institute, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Immunology, Children's Memorial Health Institute, Warsaw</wicri:regionArea>
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<author>
<name sortKey="Cowan, Morton J" sort="Cowan, Morton J" uniqKey="Cowan M" first="Morton J" last="Cowan">Morton J. Cowan</name>
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<nlm:affiliation>Allergy Immunology and Blood and Marrow Transplant Division, University of California San Francisco Benioff Children's Hospital, San Francisco, Calif.</nlm:affiliation>
<wicri:noCountry code="subField">Calif</wicri:noCountry>
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<name sortKey="Fischer, Alain" sort="Fischer, Alain" uniqKey="Fischer A" first="Alain" last="Fischer">Alain Fischer</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris</wicri:regionArea>
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<region type="region">Île-de-France</region>
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<author>
<name sortKey="Gennery, Andrew R" sort="Gennery, Andrew R" uniqKey="Gennery A" first="Andrew R" last="Gennery">Andrew R. Gennery</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: a.r.gennery@ncl.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<title xml:lang="en">Outcome of hematopoietic cell transplantation for DNA double-strand break repair disorders.</title>
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<name sortKey="Slack, James" sort="Slack, James" uniqKey="Slack J" first="James" last="Slack">James Slack</name>
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<nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<author>
<name sortKey="Albert, Michael H" sort="Albert, Michael H" uniqKey="Albert M" first="Michael H" last="Albert">Michael H. Albert</name>
<affiliation wicri:level="3">
<nlm:affiliation>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
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<region type="land" nuts="1">Bavière</region>
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<settlement type="city">Munich</settlement>
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</author>
<author>
<name sortKey="Balashov, Dmitry" sort="Balashov, Dmitry" uniqKey="Balashov D" first="Dmitry" last="Balashov">Dmitry Balashov</name>
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<nlm:affiliation>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow</wicri:regionArea>
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<settlement type="city">Moscou</settlement>
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</affiliation>
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<author>
<name sortKey="Belohradsky, Bernd H" sort="Belohradsky, Bernd H" uniqKey="Belohradsky B" first="Bernd H" last="Belohradsky">Bernd H. Belohradsky</name>
<affiliation wicri:level="3">
<nlm:affiliation>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
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<name sortKey="Bertaina, Alice" sort="Bertaina, Alice" uniqKey="Bertaina A" first="Alice" last="Bertaina">Alice Bertaina</name>
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<nlm:affiliation>Stem Cell Transplant Unit, Department of Hematology and Oncology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Stem Cell Transplant Unit, Department of Hematology and Oncology, Ospedale Pediatrico Bambino Gesù, Rome</wicri:regionArea>
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<settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
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<author>
<name sortKey="Bleesing, Jack" sort="Bleesing, Jack" uniqKey="Bleesing J" first="Jack" last="Bleesing">Jack Bleesing</name>
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<nlm:affiliation>Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Ohio</region>
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<wicri:cityArea>Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati</wicri:cityArea>
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</author>
<author>
<name sortKey="Booth, Claire" sort="Booth, Claire" uniqKey="Booth C" first="Claire" last="Booth">Claire Booth</name>
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<nlm:affiliation>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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</affiliation>
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<author>
<name sortKey="Buechner, Jochen" sort="Buechner, Jochen" uniqKey="Buechner J" first="Jochen" last="Buechner">Jochen Buechner</name>
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<nlm:affiliation>Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo</wicri:regionArea>
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<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
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<author>
<name sortKey="Buckley, Rebecca H" sort="Buckley, Rebecca H" uniqKey="Buckley R" first="Rebecca H" last="Buckley">Rebecca H. Buckley</name>
<affiliation wicri:level="2">
<nlm:affiliation>Duke University School of Medicine, Departments of Pediatrics and Immunology, Duke University Medical Center, Durham, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University School of Medicine, Departments of Pediatrics and Immunology, Duke University Medical Center, Durham</wicri:cityArea>
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<author>
<name sortKey="Ouachee Chardin, Marie" sort="Ouachee Chardin, Marie" uniqKey="Ouachee Chardin M" first="Marie" last="Ouachée-Chardin">Marie Ouachée-Chardin</name>
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<nlm:affiliation>Paediatric BMT Unit, Robert Debre Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paediatric BMT Unit, Robert Debre Hospital, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Deripapa, Elena" sort="Deripapa, Elena" uniqKey="Deripapa E" first="Elena" last="Deripapa">Elena Deripapa</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow</wicri:regionArea>
<placeName>
<settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Drabko, Katarzyna" sort="Drabko, Katarzyna" uniqKey="Drabko K" first="Katarzyna" last="Drabko">Katarzyna Drabko</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name>
<affiliation>
<nlm:affiliation>Center for International Blood and Marrow Transplant Research, Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wis.</nlm:affiliation>
<wicri:noCountry code="subField">Wis</wicri:noCountry>
</affiliation>
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<author>
<name sortKey="Feuchtinger, Tobias" sort="Feuchtinger, Tobias" uniqKey="Feuchtinger T" first="Tobias" last="Feuchtinger">Tobias Feuchtinger</name>
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<nlm:affiliation>Department of Haematology and Oncology, University Children's Hospital Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Haematology and Oncology, University Children's Hospital Tübingen, Tübingen</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
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</affiliation>
</author>
<author>
<name sortKey="Finocchi, Andrea" sort="Finocchi, Andrea" uniqKey="Finocchi A" first="Andrea" last="Finocchi">Andrea Finocchi</name>
<affiliation>
<nlm:affiliation>Department of Systems Medicine, University of Rome "Tor Vergata", Unit of Immune and Infectious Diseases, Children's Hospital Bambino Gesù, Rome, Itlay.</nlm:affiliation>
<wicri:noCountry code="subField">Itlay</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name>
<affiliation wicri:level="3">
<nlm:affiliation>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ghosh, Sujal" sort="Ghosh, Sujal" uniqKey="Ghosh S" first="Sujal" last="Ghosh">Sujal Ghosh</name>
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<nlm:affiliation>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Düsseldorf</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gillio, Alfred" sort="Gillio, Alfred" uniqKey="Gillio A" first="Alfred" last="Gillio">Alfred Gillio</name>
<affiliation wicri:level="2">
<nlm:affiliation>Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">New Jersey</region>
</placeName>
<wicri:cityArea>Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Gonzalez Granado, Luis I" sort="Gonzalez Granado, Luis I" uniqKey="Gonzalez Granado L" first="Luis I" last="Gonzalez-Granado">Luis I. Gonzalez-Granado</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immunodeficiencies, Hematology & Oncology Unit, Pediatrics, Hospital 12 Octubre, and Universidad Complutense, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Immunodeficiencies, Hematology & Oncology Unit, Pediatrics, Hospital 12 Octubre, and Universidad Complutense, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grunebaum, Eyal" sort="Grunebaum, Eyal" uniqKey="Grunebaum E" first="Eyal" last="Grunebaum">Eyal Grunebaum</name>
<affiliation wicri:level="4">
<nlm:affiliation>Division of Immunology and Allergy, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Immunology and Allergy, Hospital for Sick Children, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName>
<settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gungor, Tayfun" sort="Gungor, Tayfun" uniqKey="Gungor T" first="Tayfun" last="Güngör">Tayfun Güngör</name>
<affiliation wicri:level="3">
<nlm:affiliation>Division of Stem Cell Transplantation, University Children's Hospital Zürich, Zürich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Division of Stem Cell Transplantation, University Children's Hospital Zürich, Zürich</wicri:regionArea>
<placeName>
<settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Heilmann, Carsten" sort="Heilmann, Carsten" uniqKey="Heilmann C" first="Carsten" last="Heilmann">Carsten Heilmann</name>
<affiliation wicri:level="3">
<nlm:affiliation>BørneUngeKlinikken, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>BørneUngeKlinikken, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Helminen, Merja" sort="Helminen, Merja" uniqKey="Helminen M" first="Merja" last="Helminen">Merja Helminen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Paediatric Research Center, University Hospital of Tampere, Tampere, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Paediatric Research Center, University Hospital of Tampere, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Higuchi, Kohei" sort="Higuchi, Kohei" uniqKey="Higuchi K" first="Kohei" last="Higuchi">Kohei Higuchi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Imai, Kohsuke" sort="Imai, Kohsuke" uniqKey="Imai K" first="Kohsuke" last="Imai">Kohsuke Imai</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kalwak, Krzysztof" sort="Kalwak, Krzysztof" uniqKey="Kalwak K" first="Krzysztof" last="Kalwak">Krzysztof Kalwak</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University, Wroclaw</wicri:regionArea>
<wicri:noRegion>Wroclaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kanazawa, Nubuo" sort="Kanazawa, Nubuo" uniqKey="Kanazawa N" first="Nubuo" last="Kanazawa">Nubuo Kanazawa</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Dermatology, Wakayama Medical University, Wakayama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Dermatology, Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Karasu, Gulsun" sort="Karasu, Gulsun" uniqKey="Karasu G" first="Gülsün" last="Karasu">Gülsün Karasu</name>
<affiliation wicri:level="1">
<nlm:affiliation>Bahcesehir University Faculty of Medicine, Göztepe Medicalpark Hospital Pediatric Stem Cell Transplantation Unit, Istanbul, Turkey.</nlm:affiliation>
<country xml:lang="fr">Turquie</country>
<wicri:regionArea>Bahcesehir University Faculty of Medicine, Göztepe Medicalpark Hospital Pediatric Stem Cell Transplantation Unit, Istanbul</wicri:regionArea>
<wicri:noRegion>Istanbul</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kucuk, Zeynep Y" sort="Kucuk, Zeynep Y" uniqKey="Kucuk Z" first="Zeynep Y" last="Kucuk">Zeynep Y. Kucuk</name>
<affiliation wicri:level="2">
<nlm:affiliation>Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Laberko, Alexandra" sort="Laberko, Alexandra" uniqKey="Laberko A" first="Alexandra" last="Laberko">Alexandra Laberko</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Immunology and Hematopoietic Stem Cell Transplantation Department, Federal Research Center for Pediatric Hematology, Oncology and Immunology, Moscow</wicri:regionArea>
<placeName>
<settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lange, Andrzej" sort="Lange, Andrzej" uniqKey="Lange A" first="Andrzej" last="Lange">Andrzej Lange</name>
<affiliation wicri:level="1">
<nlm:affiliation>Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences / Lower Silesian Center for Cellular Transplantation, Wrocław, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences / Lower Silesian Center for Cellular Transplantation, Wrocław</wicri:regionArea>
<wicri:noRegion>Wrocław</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mahlaoui, Nizar" sort="Mahlaoui, Nizar" uniqKey="Mahlaoui N" first="Nizar" last="Mahlaoui">Nizar Mahlaoui</name>
<affiliation wicri:level="3">
<nlm:affiliation>French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Reference Center for Primary Immune Deficiencies (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Meisel, Roland" sort="Meisel, Roland" uniqKey="Meisel R" first="Roland" last="Meisel">Roland Meisel</name>
<affiliation wicri:level="3">
<nlm:affiliation>Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Düsseldorf</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moshous, D" sort="Moshous, D" uniqKey="Moshous D" first="D" last="Moshous">D. Moshous</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Muramatsu, Hideki" sort="Muramatsu, Hideki" uniqKey="Muramatsu H" first="Hideki" last="Muramatsu">Hideki Muramatsu</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Parikh, Suhag" sort="Parikh, Suhag" uniqKey="Parikh S" first="Suhag" last="Parikh">Suhag Parikh</name>
<affiliation wicri:level="2">
<nlm:affiliation>Duke University School of Medicine, Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University School of Medicine, Pediatric Blood and Marrow Transplant Program, Duke University Medical Center, Durham</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Pasic, Srdjan" sort="Pasic, Srdjan" uniqKey="Pasic S" first="Srdjan" last="Pasic">Srdjan Pasic</name>
<affiliation wicri:level="1">
<nlm:affiliation>Mother and Child Health Institute, Medical Faculty, University of Belgrade, Belgrade, Serbia.</nlm:affiliation>
<country xml:lang="fr">Serbie</country>
<wicri:regionArea>Mother and Child Health Institute, Medical Faculty, University of Belgrade, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schmid, Irene" sort="Schmid, Irene" uniqKey="Schmid I" first="Irene" last="Schmid">Irene Schmid</name>
<affiliation wicri:level="3">
<nlm:affiliation>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. von Hauner University Children's Hospital, Ludwig-Maximilians-Universität, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schuetz, Catharina" sort="Schuetz, Catharina" uniqKey="Schuetz C" first="Catharina" last="Schuetz">Catharina Schuetz</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schulz, Ansgar" sort="Schulz, Ansgar" uniqKey="Schulz A" first="Ansgar" last="Schulz">Ansgar Schulz</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R" last="Schultz">Kirk R. Schultz</name>
<affiliation wicri:level="1">
<nlm:affiliation>Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital and Child and Family Research Institute, Vancouver, British Columbia</wicri:regionArea>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J" last="Shaw">Peter J. Shaw</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Oncology, Children's Hospital at Westmead, Westmead, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Oncology, Children's Hospital at Westmead, Westmead</wicri:regionArea>
<wicri:noRegion>Westmead</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Slatter, Mary A" sort="Slatter, Mary A" uniqKey="Slatter M" first="Mary A" last="Slatter">Mary A. Slatter</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sykora, Karl Walter" sort="Sykora, Karl Walter" uniqKey="Sykora K" first="Karl-Walter" last="Sykora">Karl-Walter Sykora</name>
<affiliation wicri:level="3">
<nlm:affiliation>Department of Pediatric Hematology Oncology, Hannover Medical, Hannover, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Hematology Oncology, Hannover Medical, Hannover</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tamura, Shinobu" sort="Tamura, Shinobu" uniqKey="Tamura S" first="Shinobu" last="Tamura">Shinobu Tamura</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Hematology and Oncology, Wakayama Medical University, Wakayama, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hematology and Oncology, Wakayama Medical University, Wakayama</wicri:regionArea>
<wicri:noRegion>Wakayama</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Taskinen, Mervi" sort="Taskinen, Mervi" uniqKey="Taskinen M" first="Mervi" last="Taskinen">Mervi Taskinen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Helsinki University Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wawer, Angela" sort="Wawer, Angela" uniqKey="Wawer A" first="Angela" last="Wawer">Angela Wawer</name>
<affiliation wicri:level="4">
<nlm:affiliation>Paediatric Haematology & Oncology, Kinderklinik der Technische Universität München, Krankenhaus München-Schwabing, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Paediatric Haematology & Oncology, Kinderklinik der Technische Universität München, Krankenhaus München-Schwabing, Munich</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wolska Kus Nierz, Beata" sort="Wolska Kus Nierz, Beata" uniqKey="Wolska Kus Nierz B" first="Beata" last="Wolska-Kus Nierz">Beata Wolska-Kus Nierz</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Immunology, Children's Memorial Health Institute, Warsaw, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Immunology, Children's Memorial Health Institute, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cowan, Morton J" sort="Cowan, Morton J" uniqKey="Cowan M" first="Morton J" last="Cowan">Morton J. Cowan</name>
<affiliation>
<nlm:affiliation>Allergy Immunology and Blood and Marrow Transplant Division, University of California San Francisco Benioff Children's Hospital, San Francisco, Calif.</nlm:affiliation>
<wicri:noCountry code="subField">Calif</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Fischer, Alain" sort="Fischer, Alain" uniqKey="Fischer A" first="Alain" last="Fischer">Alain Fischer</name>
<affiliation wicri:level="3">
<nlm:affiliation>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Immuno-Hematology Unit, Necker Children's Hospital, Assistance Publique Hôpitaux de Paris, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gennery, Andrew R" sort="Gennery, Andrew R" uniqKey="Gennery A" first="Andrew R" last="Gennery">Andrew R. Gennery</name>
<affiliation wicri:level="1">
<nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: a.r.gennery@ncl.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">The Journal of allergy and clinical immunology</title>
<idno type="eISSN">1097-6825</idno>
<imprint>
<date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Rare DNA breakage repair disorders predispose to infection and lymphoreticular malignancies. Hematopoietic cell transplantation (HCT) is curative, but coadministered chemotherapy or radiotherapy is damaging because of systemic radiosensitivity. We collected HCT outcome data for Nijmegen breakage syndrome, DNA ligase IV deficiency, Cernunnos-XRCC4-like factor (Cernunnos-XLF) deficiency, and ataxia-telangiectasia (AT).</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>Espagne</li>
<li>Finlande</li>
<li>France</li>
<li>Italie</li>
<li>Japon</li>
<li>Norvège</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>Serbie</li>
<li>Suisse</li>
<li>Turquie</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>Basse-Saxe</li>
<li>Bavière</li>
<li>Canton de Zurich</li>
<li>Caroline du Nord</li>
<li>Communauté de Madrid</li>
<li>District de Düsseldorf</li>
<li>District de Haute-Bavière</li>
<li>District de Tübingen</li>
<li>District fédéral central</li>
<li>Grand Londres</li>
<li>Hovedstaden</li>
<li>Latium</li>
<li>New Jersey</li>
<li>Ohio</li>
<li>Ontario</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Région de Kantō</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement>
<li>Copenhague</li>
<li>Düsseldorf</li>
<li>Hanovre</li>
<li>Londres</li>
<li>Madrid</li>
<li>Moscou</li>
<li>Munich</li>
<li>Oslo</li>
<li>Paris</li>
<li>Rome</li>
<li>Tokyo</li>
<li>Toronto</li>
<li>Tübingen</li>
<li>Ulm</li>
<li>Zurich</li>
</settlement>
<orgName>
<li>Université Louis-et-Maximilien de Munich</li>
<li>Université de Toronto</li>
</orgName>
</list>
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<name sortKey="Cowan, Morton J" sort="Cowan, Morton J" uniqKey="Cowan M" first="Morton J" last="Cowan">Morton J. Cowan</name>
<name sortKey="Eapen, Mary" sort="Eapen, Mary" uniqKey="Eapen M" first="Mary" last="Eapen">Mary Eapen</name>
<name sortKey="Finocchi, Andrea" sort="Finocchi, Andrea" uniqKey="Finocchi A" first="Andrea" last="Finocchi">Andrea Finocchi</name>
</noCountry>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Slack, James" sort="Slack, James" uniqKey="Slack J" first="James" last="Slack">James Slack</name>
</noRegion>
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<name sortKey="Gaspar, H Bobby" sort="Gaspar, H Bobby" uniqKey="Gaspar H" first="H Bobby" last="Gaspar">H Bobby Gaspar</name>
<name sortKey="Gennery, Andrew R" sort="Gennery, Andrew R" uniqKey="Gennery A" first="Andrew R" last="Gennery">Andrew R. Gennery</name>
<name sortKey="Slatter, Mary A" sort="Slatter, Mary A" uniqKey="Slatter M" first="Mary A" last="Slatter">Mary A. Slatter</name>
</country>
<country name="Allemagne">
<region name="Bavière">
<name sortKey="Albert, Michael H" sort="Albert, Michael H" uniqKey="Albert M" first="Michael H" last="Albert">Michael H. Albert</name>
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<name sortKey="Schmid, Irene" sort="Schmid, Irene" uniqKey="Schmid I" first="Irene" last="Schmid">Irene Schmid</name>
<name sortKey="Schuetz, Catharina" sort="Schuetz, Catharina" uniqKey="Schuetz C" first="Catharina" last="Schuetz">Catharina Schuetz</name>
<name sortKey="Schulz, Ansgar" sort="Schulz, Ansgar" uniqKey="Schulz A" first="Ansgar" last="Schulz">Ansgar Schulz</name>
<name sortKey="Sykora, Karl Walter" sort="Sykora, Karl Walter" uniqKey="Sykora K" first="Karl-Walter" last="Sykora">Karl-Walter Sykora</name>
<name sortKey="Wawer, Angela" sort="Wawer, Angela" uniqKey="Wawer A" first="Angela" last="Wawer">Angela Wawer</name>
</country>
<country name="Russie">
<region name="District fédéral central">
<name sortKey="Balashov, Dmitry" sort="Balashov, Dmitry" uniqKey="Balashov D" first="Dmitry" last="Balashov">Dmitry Balashov</name>
</region>
<name sortKey="Deripapa, Elena" sort="Deripapa, Elena" uniqKey="Deripapa E" first="Elena" last="Deripapa">Elena Deripapa</name>
<name sortKey="Laberko, Alexandra" sort="Laberko, Alexandra" uniqKey="Laberko A" first="Alexandra" last="Laberko">Alexandra Laberko</name>
</country>
<country name="Italie">
<region name="Latium">
<name sortKey="Bertaina, Alice" sort="Bertaina, Alice" uniqKey="Bertaina A" first="Alice" last="Bertaina">Alice Bertaina</name>
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</country>
<country name="États-Unis">
<region name="Ohio">
<name sortKey="Bleesing, Jack" sort="Bleesing, Jack" uniqKey="Bleesing J" first="Jack" last="Bleesing">Jack Bleesing</name>
</region>
<name sortKey="Buckley, Rebecca H" sort="Buckley, Rebecca H" uniqKey="Buckley R" first="Rebecca H" last="Buckley">Rebecca H. Buckley</name>
<name sortKey="Gillio, Alfred" sort="Gillio, Alfred" uniqKey="Gillio A" first="Alfred" last="Gillio">Alfred Gillio</name>
<name sortKey="Kucuk, Zeynep Y" sort="Kucuk, Zeynep Y" uniqKey="Kucuk Z" first="Zeynep Y" last="Kucuk">Zeynep Y. Kucuk</name>
<name sortKey="Parikh, Suhag" sort="Parikh, Suhag" uniqKey="Parikh S" first="Suhag" last="Parikh">Suhag Parikh</name>
</country>
<country name="Norvège">
<region name="Østlandet">
<name sortKey="Buechner, Jochen" sort="Buechner, Jochen" uniqKey="Buechner J" first="Jochen" last="Buechner">Jochen Buechner</name>
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</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Ouachee Chardin, Marie" sort="Ouachee Chardin, Marie" uniqKey="Ouachee Chardin M" first="Marie" last="Ouachée-Chardin">Marie Ouachée-Chardin</name>
</region>
<name sortKey="Fischer, Alain" sort="Fischer, Alain" uniqKey="Fischer A" first="Alain" last="Fischer">Alain Fischer</name>
<name sortKey="Mahlaoui, Nizar" sort="Mahlaoui, Nizar" uniqKey="Mahlaoui N" first="Nizar" last="Mahlaoui">Nizar Mahlaoui</name>
<name sortKey="Moshous, D" sort="Moshous, D" uniqKey="Moshous D" first="D" last="Moshous">D. Moshous</name>
</country>
<country name="Pologne">
<noRegion>
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<name sortKey="Kalwak, Krzysztof" sort="Kalwak, Krzysztof" uniqKey="Kalwak K" first="Krzysztof" last="Kalwak">Krzysztof Kalwak</name>
<name sortKey="Lange, Andrzej" sort="Lange, Andrzej" uniqKey="Lange A" first="Andrzej" last="Lange">Andrzej Lange</name>
<name sortKey="Wolska Kus Nierz, Beata" sort="Wolska Kus Nierz, Beata" uniqKey="Wolska Kus Nierz B" first="Beata" last="Wolska-Kus Nierz">Beata Wolska-Kus Nierz</name>
</country>
<country name="Espagne">
<region name="Communauté de Madrid">
<name sortKey="Gonzalez Granado, Luis I" sort="Gonzalez Granado, Luis I" uniqKey="Gonzalez Granado L" first="Luis I" last="Gonzalez-Granado">Luis I. Gonzalez-Granado</name>
</region>
</country>
<country name="Canada">
<region name="Ontario">
<name sortKey="Grunebaum, Eyal" sort="Grunebaum, Eyal" uniqKey="Grunebaum E" first="Eyal" last="Grunebaum">Eyal Grunebaum</name>
</region>
<name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R" last="Schultz">Kirk R. Schultz</name>
</country>
<country name="Suisse">
<region name="Canton de Zurich">
<name sortKey="Gungor, Tayfun" sort="Gungor, Tayfun" uniqKey="Gungor T" first="Tayfun" last="Güngör">Tayfun Güngör</name>
</region>
</country>
<country name="Danemark">
<region name="Hovedstaden">
<name sortKey="Heilmann, Carsten" sort="Heilmann, Carsten" uniqKey="Heilmann C" first="Carsten" last="Heilmann">Carsten Heilmann</name>
</region>
</country>
<country name="Finlande">
<noRegion>
<name sortKey="Helminen, Merja" sort="Helminen, Merja" uniqKey="Helminen M" first="Merja" last="Helminen">Merja Helminen</name>
</noRegion>
<name sortKey="Taskinen, Mervi" sort="Taskinen, Mervi" uniqKey="Taskinen M" first="Mervi" last="Taskinen">Mervi Taskinen</name>
</country>
<country name="Japon">
<noRegion>
<name sortKey="Higuchi, Kohei" sort="Higuchi, Kohei" uniqKey="Higuchi K" first="Kohei" last="Higuchi">Kohei Higuchi</name>
</noRegion>
<name sortKey="Imai, Kohsuke" sort="Imai, Kohsuke" uniqKey="Imai K" first="Kohsuke" last="Imai">Kohsuke Imai</name>
<name sortKey="Kanazawa, Nubuo" sort="Kanazawa, Nubuo" uniqKey="Kanazawa N" first="Nubuo" last="Kanazawa">Nubuo Kanazawa</name>
<name sortKey="Muramatsu, Hideki" sort="Muramatsu, Hideki" uniqKey="Muramatsu H" first="Hideki" last="Muramatsu">Hideki Muramatsu</name>
<name sortKey="Tamura, Shinobu" sort="Tamura, Shinobu" uniqKey="Tamura S" first="Shinobu" last="Tamura">Shinobu Tamura</name>
</country>
<country name="Turquie">
<noRegion>
<name sortKey="Karasu, Gulsun" sort="Karasu, Gulsun" uniqKey="Karasu G" first="Gülsün" last="Karasu">Gülsün Karasu</name>
</noRegion>
</country>
<country name="Serbie">
<noRegion>
<name sortKey="Pasic, Srdjan" sort="Pasic, Srdjan" uniqKey="Pasic S" first="Srdjan" last="Pasic">Srdjan Pasic</name>
</noRegion>
</country>
<country name="Australie">
<noRegion>
<name sortKey="Shaw, Peter J" sort="Shaw, Peter J" uniqKey="Shaw P" first="Peter J" last="Shaw">Peter J. Shaw</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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